Study on effectiveness and user satisfaction of anti-inflammatory ointment of Curcuma albiflora Thw. in Bentota divisional secretariat, Southern Sri Lanka

Indika Chandralal Herath, T.D.C.M.K. Wijayasiriwardene, G.A.S. Premakumara

Abstract


Under the same Sinhalese vernacular name, three plants (C. albiflora Thw., C. zedoaria Rosc., and Zingiber zerumbet Smith.) are being reported. Amongst them, C. albiflora is an endangered and less explored plant. The current study was conducted to study anti-inflammatory activity of the ointment, which was produced using C. albiflora. Clinical trial was conducted using 175 people in community based centers in two gramaniladari divisions of Bentota Divisional Secretariat, Southern Province of Sri Lanka. Patients were asked to complete a structured questionnaire based on which treatment (98 indicidials) and placebo (77 individuals) group was identified. Treatment was conducted for two weeks and the results monitored by the two traditional medicine (TM) doctors used for the analysis. Comparisons by chi square test showed that TM users and non-users did not differ with respect to previous side effects and current inflammatory condition (P<0.05). By binary logistic regression analysis, a treatment group satisfaction was about 88 times the chance of the placebo group. The binary logistic models indicated that patients with age more than 60 years, female, previous traditional medicine users, duration of current anti-inflammatory condition not less than one year were more likely to effectively response. Ointment of C. albiflora Thw. showed significant anti-inflammatory activity.

Full Text:

PDF

References


Anand A, Bansal G. 2016. Predicting Customer’s Satisfaction (Dissatisfaction) Using Logistic Regression. International Journal of Mathematical, Engineering and Management Sciences 1(2): 77–88.

Angel GR, Vimala B, Nambisan B. 2013. Antioxidant and anti-inflammatory activities of proteins isolated from eight Curcuma species. Phytopharmacology 4(1): 96-105.

Dassanayaka MD. 1983. Flora of Ceylon, Vol IV. Amerind Publishing Co. Pvt. Ltd, New Delhi 495 – 496, 501-504.

DCS. 2014. National Survey on Self-reported Health in Sri Lanka 2014. Department of Census and Statistics. Sri Lanka: Ministry of National Policies and Economic Affairs.

Gonçalves S, Silva GH, Barros PD, Srebernich SM, Shiraishi CTC, Camargos VR, Lasca TB. 2014. Use of Curcuma longa in cosmetics: extraction of curcuminoid pigments, development of formulations, and in vitro skin permeation studies. Brazilian Journal of Pharmaceutical Sciences 50(4): 885-893.

Gustin DM, Brenner DE. 2002. Chemoprevention of colon cancer: current status and future prospects. Cancer and Metastasis Reviews 21:323-348.

Hamzah MM. 2011. Evaluation of topical preparations containing curcuma, acacia and lupinus extracts as an anti-inflammatory drugs. International Journal of Applied Research in Natural Products 4(2): 19-23.

Herath I, Premakumara S, Wijayasiriwardene C. 2017. Anti-inflammatory activity of Curcuma albiflora Thw. grown in Sri Lanka. Journal of Ayurveda Medical Sciences 2(4): 90-93.

Huang MT, Yen P, Xie J, Han J, Frenkel J. 1997. Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetateinduced tumor promotion and oxidized DNA bases in mouse epidermis. Carcinogenesis 18(1): 83-88.

Kankanamalage TN, Dharmadasa RM, Abeysinghe DC, Wijesekara RG. 2014. A Survey on Medicinal Materials Used in Traditional Systems of Medicine in Sri Lanka. Journal of Ethnopharmacology 155 (1):679–91.

Kaushik ML, Jalalpure SS. 2011. Anti-inflammatory Efficacy of Curcuma Zedoaria Root Extracts. Asian Journal of Pharmaceutical and Clinical Research 4(3):1-5.

Kaushik ML, Jalalpure SS. 2011. Effect of Curcuma zedoaria Rosc root extracts on behavioral and radiology changes in arthritic rats. Journal of Advance Pharmaceutical Technology & Reaserch 2(3): 170-176.

Kuptniratsaikul V, Thanakhumtorn S, Chinswangwatanakul P, Wattanamongkonsil L, Visanu T. 2009. Efficacy and Safety of Curcuma domestica Extracts in Patients with Knee Osteoarthritis. Journal of Alternative Complementary Medicine 15(8):891-897.

Liu TG, Xiong SQ, Yan Y, Zhu H, Yi C. 2012. Use of Chinese Herb Medicine in Cancer Patients: A Survey in Southwestern China. Evidence-Based Complementary and Alternative Medicine: 7.

Lin CL, Lin JK. 2008. Curcumin: a potential cancer chemopreventive agent through suppressing NF-ıB signaling. Journal of Cancer Molecules 4(1): 11-16.

Makabe H, Maru N, Kuwabara A, Kamo T, Hirota M. 2006. Anti-inflammatory sesquiterpenes from Curcuma zedoaria. Natural Product Research 20(7): 680-685.

MOE. 2012. The National Red List 2012 of Sri Lanka, Conservation Status of the Fauna and Flora. Sri Lanka: Ministry of Environment, 339p.

O’Leary MR. 2014. Dr. Thomas Addison 1795-1860. USA: iUniverse.

Peng CYJ. 2002. An Introduction to Logistic Regression Analysis and Reporting. The Journal of Educational Research, 3-14.

Richette, P, Bardin T. 2010. Gout. Lancet 375(9711):318.

Shanks N, Greek R, Greek J. 2009. Are animals models predictive for humans?. Philosophy, Ethics and Humanities in Medicine 4: 2.

Swisher, EM, Cohn DE, Goff BA. 2002. Use of complementary and alternative medicine among women with gynecologic cancers. Gynecologic Oncology 84(3): 363–367.

Ullah HMA, Zaman S, Juhara F, et al. 2014. Evaluation of antinociceptive, in-vivo & in-vitro anti-inflammatory activity of ethanolic extract of Curcuma zedoaria rhizome. BMC Complementary Alternative Medicine 14(1): 1-12.


Refbacks

  • There are currently no refbacks.


Creative Commons Licence
Ruhuna Journal of Science by University of Ruhuna is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

eISSN: 2536-8400

Print ISSN: 1800-279X (Before 2014)